Dupixent's patient assistance application is buried inside a single, dense enrollment form that also handles insurance investigation and copay-card sign-up, which is a big reason people get confused about what they're actually applying for. This guide separates the three DUPIXENT MyWay programs, explains the flat $100,000 income rule and how it's actually checked, and walks through what to expect after you submit the paperwork — including the fine print that trips people up, like the "alternative funding program" exclusion almost no one hears about until they're denied.
1. What the Patient Assistance Program Actually Provides
The DUPIXENT MyWay Patient Assistance Program is a charitable access program run jointly by Sanofi and Regeneron (referred to on the enrollment paperwork as "the Alliance"). If you're approved, Dupixent is provided to you completely free — not discounted, not a coupon, but at no cost — typically dispensed through a specialty pharmacy the same way an insured patient's prescription would be. It sits underneath the broader DUPIXENT MyWay umbrella, which also handles insurance coverage support, injection training, and refill reminders for every Dupixent patient, insured or not.
2. Three Dupixent Programs — Don't Confuse Them
Most of the confusion around Dupixent assistance comes from three different programs sharing the DUPIXENT MyWay name. They serve different patients and use different rules, and mixing them up is the single most common reason people think they've been denied something they never actually applied for.
| Program | Who it's for | What it does | Income-based? |
|---|---|---|---|
| Copay Card | Commercially insured patients | As little as $0 copay per fill, up to $13,000/year | No |
| Patient Assistance Program | Uninsured, insurance doesn't cover Dupixent, or Medicare Part D | Free Dupixent, provided at no cost | Yes — $100,000 AGI limit |
| Quick Start Program | Commercially insured patients only, during a coverage delay | Temporary free bridge supply while prior authorization or an appeal is pending | No |
Only the middle row — the Patient Assistance Program — is what most people mean when they search for "Dupixent financial assistance" as an uninsured or underinsured patient. The other two are worth knowing about so you don't apply to the wrong one.
3. Full Eligibility Requirements
| Requirement | Detail |
|---|---|
| Age | 18 years or older |
| Residency | The 50 United States, Washington DC, Puerto Rico, Guam, or the USVI |
| Insurance status | Uninsured, insurance that doesn't cover Dupixent, or Medicare Part D |
| Commercial/employer insurance | Disqualifying — use the Copay Card instead |
| Household income | Total annual adjusted gross income of $100,000 or less |
| Plan uses an "alternative funding program" vendor | Disqualifying |
| Prescription | Must be for an FDA-approved Dupixent indication |
| Prescriber signature | Required on the enrollment form's prescriber section |
Medicaid isn't explicitly listed as a qualifying category for the Patient Assistance Program the way Medicare Part D is. Most Medicaid programs already cover Dupixent at a low copay (commonly $4–$8/month), and the Copay Card explicitly excludes Medicaid. If you're on Medicaid and still can't afford your copay, call DUPIXENT MyWay directly rather than assuming either program applies to your situation.
4. The $100,000 Income Rule Explained
This is the detail that surprises people who've researched other manufacturers' assistance programs first. Many patient assistance programs scale their income limit to a percentage of the federal poverty level, so a family of five can earn considerably more than a single person and still qualify. Dupixent's Patient Assistance Program doesn't work that way. The published threshold is a single flat number — $100,000 in total annual adjusted gross income — and it applies the same whether you're a household of one or a household of six.
That cuts both ways. A single person earning $95,000 qualifies on income alone, same as a family of five earning $95,000. But a family of six earning $105,000 — a income level some FPL-scaled programs would still cover — would not meet Dupixent's threshold as published.
Confirm the current figure before applying. Manufacturer assistance program terms can change without notice, and DUPIXENT MyWay reserves the right to revise eligibility criteria at any time. Treat $100,000 as the figure published as of this guide's date and verify it directly with a DUPIXENT MyWay Case Manager at 1-844-387-4936 when you apply.
5. How Income Is Actually Verified
Most manufacturer patient assistance programs ask you to mail in pay stubs, a tax return, or an unemployment statement before they'll approve anything. Dupixent's enrollment form takes a different approach: it includes a "Credit Check Consent" section authorizing the Alliance, under the Fair Credit Reporting Act, to pull a consumer report and use it — along with other information it collects — to estimate your income as part of the eligibility determination, rather than requiring documentation upfront.
In practice, that means many applicants aren't asked to submit pay stubs or a tax return at all. But it's not a guarantee: if the credit-based estimate doesn't clearly resolve your eligibility, a case manager may still contact you or your prescriber's office for income documentation. It's worth having recent pay stubs, a tax return, or an unemployment statement on hand in case that happens, even though the form doesn't require you to attach them by default.
6. Decision Tree: Which Program Fits You?
If income puts you over the manufacturer's threshold, NeedyMeds, RxAssist, and state pharmaceutical assistance programs are worth checking before assuming you're stuck paying full price.
7. Step-by-Step: How to Apply
Talk to your prescriber about DUPIXENT MyWay
You can start the process by calling DUPIXENT MyWay yourself, but your prescriber's office needs to be involved — the enrollment form has a clinical section only they can complete and sign.
Complete the shared enrollment form together
The form covers your patient information, insurance status, consent to a benefits investigation, your prescriber's diagnosis and prescription, and your signed authorizations — including the credit-check consent used to estimate income. There is no separate, stand-alone "Patient Assistance Program application" to fill out.
Submit it by fax or the online portal
Your prescriber's office typically submits the completed form by fax to 1-844-387-9370, or electronically through DUPIXENTMyWayPortal.com.
Wait for a case manager to reach out
DUPIXENT MyWay states that a case manager typically reaches out by phone or email within a few days of the form being submitted to begin support. Determining Patient Assistance Program eligibility specifically — including any income-estimate follow-up — can take longer than that initial contact.
If approved, your prescription is routed to a specialty pharmacy
Approved Patient Assistance Program prescriptions are typically filled and shipped the way any Dupixent prescription would be, coordinated by your DUPIXENT MyWay case manager and your prescriber's office.
8. What Happens After You're Approved
A few conditions apply once you're receiving free Dupixent through the program, and they're worth knowing upfront rather than discovering later:
- You must notify DUPIXENT MyWay if your insurance situation changes. Gaining or losing coverage can move you between the Patient Assistance Program and the Copay Card.
- Continued participation depends on "timely verification of income." Dupixent doesn't publish a fixed reapplication schedule, but staying enrolled requires the program to be able to re-verify your eligibility when asked.
- Your signed authorization is valid for up to five years from the date you sign it, or until your state requires it to expire sooner — Maryland residents' authorizations expire after one year specifically.
- The free medication can't be billed to any payer, including Medicare or Medicaid, and can't be resold, traded, or distributed.
- If you have Medicare Part D, the value of medication received through the program does not count toward your plan's true out-of-pocket (TrOOP) costs.
9. Why Applications Get Delayed or Denied
| Reason | What to do about it |
|---|---|
| Adjusted gross income above $100,000 | Double-check what counts toward AGI; if you're close to the line, ask a case manager how it's calculated for your situation |
| You have commercial or employer insurance | Not eligible for this program — apply for the Copay Card instead |
| Missing prescriber signature or incomplete form | Confirm with your prescriber's office that every section, including Section 5, was signed — no stamps are accepted |
| Your health plan uses an "alternative funding program" vendor | Review your plan benefits with your employer's HR or benefits team to confirm; if confirmed, you're not eligible for this program |
| Residency outside the eligible list | Confirm you live in one of the 50 states, DC, Puerto Rico, Guam, or the USVI |
The "alternative funding program" exclusion catches people off guard. Some employer health plans work with third-party vendors that carve specialty drugs like Dupixent out of standard coverage and require patients to apply to manufacturer assistance programs as a condition of getting the medication at all. If you were told you must work with a "patient advocate" company, or that your plan won't cover Dupixent unless a manufacturer program turns you down first, your plan may be using one of these arrangements — and the Dupixent Patient Assistance Program explicitly excludes patients in that situation. Ask your HR or benefits team directly if you're unsure.
10. Medicare Part D and the Dupixent PAP
Dupixent's Patient Assistance Program treats Medicare differently than some other manufacturer programs. Patients with Medicare Part D prescription drug coverage are explicitly named, alongside uninsured patients, as a group the program may be able to help — there's no blanket exclusion for Medicare beneficiaries here.
Before applying to the Patient Assistance Program as a Medicare patient, it's worth checking whether the Medicare Prescription Payment Plan — which lets you spread Part D drug costs into monthly installments at no extra cost — or Extra Help (the Low-Income Subsidy) already brings your cost down to something manageable. If it doesn't, the Patient Assistance Program remains an option, and if you're approved, the free medication's value won't count toward your annual Part D out-of-pocket total.
11. If You Don't Qualify: Other Options
If your income is above $100,000, your plan disqualifies you, or you're otherwise not a fit for the manufacturer's own program, a few other paths are worth checking rather than assuming full list price is your only option. Nonprofit clearinghouses like NeedyMeds and RxAssist maintain independent listings of manufacturer, state, and charitable assistance programs that use different eligibility rules than Dupixent's own. State pharmaceutical assistance programs vary by state and sometimes cover biologics like Dupixent under separate income thresholds. If you have commercial insurance but your out-of-pocket cost is still high, revisit the Dupixent Copay Card, since many commercially insured patients underestimate how much it can reduce a monthly fill.